Drug General Information
Drug ID	D0J8FE
Former ID	DIB014236
Drug Name	CDK2 inhibitors
Synonyms	CDK2 inhibitors (cancer); CDK2 inhibitors (cancer), Hoffmann-La Roche
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[552157]
Company	Hoffmann-La Roche AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c2c([nH]c3c(n1)c([nH]n3)C)ccc(c2)N)c1c(cccc1)Cl
Target and Pathway
Target(s)	Cell division protein kinase 2	Target Info	Inhibitor	[543528]
KEGG Pathway	FoxO signaling pathway
	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	PI3K-Akt signaling pathway
	Progesterone-mediated oocyte maturation
	Hepatitis B
	Measles
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Prostate cancer
	Small cell lung cancer
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	p53 pathway
	p53 pathway feedback loops 2
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by PRL
	p73 transcription factor network
	E2F transcription factor network
	ATR signaling pathway
	mTOR signaling pathway
	IL2-mediated signaling events
	FoxO family signaling
	FOXM1 transcription factor network
	BARD1 signaling events
	p53 pathway
	Regulation of retinoblastoma protein
Reactome	G0 and Early G1
	Activation of ATR in response to replication stress
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	Processing of DNA double-strand break ends
	G2 Phase
	Orc1 removal from chromatin
	Cyclin E associated events during G1/S transition
	Cyclin A/B1 associated events during G2/M transition
	p53-Dependent G1 DNA Damage Response
	Cyclin A:Cdk2-associated events at S phase entry
	Meiotic recombination
	Factors involved in megakaryocyte development and platelet production
WikiPathways	DNA Damage Response
	ID signaling pathway
	DNA Replication
	G1 to S cell cycle control
	M/G1 Transition
	S Phase
	Meiotic Recombination
	Aryl Hydrocarbon Receptor
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Synthesis of DNA
	Regulation of DNA replication
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage Response
References
Ref 552157	WO patent application no. 2000064900A1, Pyrazolobenzodiazepines as cdk2 inhibitors.
Ref 543528	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1973).

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