Drug Information

Drug General Information
Drug ID
D0K1CL
Former ID
DIB014771
Drug Name
SDZ-224-015
Synonyms
VE-13045
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Terminated [546056]
Company
Sandoz Research Institute
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C(=O)(N[C@H](C(=O)N[C@H](CC(=O)OCC)C(=O)COC(=O)c1c(Cl)c<br />ccc1Cl)C)[C@@H](NC(=O)OCc1ccccc1)C(C)C
CAS Number
CAS 161511-45-1
Target and Pathway
Target(s) Interleukin-1 beta convertase Target Info Modulator [533644]
KEGG Pathway NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Amyotrophic lateral sclerosis (ALS)
Salmonella infection
Pertussis
Legionellosis
Influenza A
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database IL1-mediated signaling events
Direct p53 effectors
IFN-gamma pathway
Cellular roles of Anthrax toxin
Reactome NOD1/2 Signaling Pathway
Interleukin-1 processing
The NLRP3 inflammasome
WikiPathways MAPK Signaling Pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Apoptosis
Amyotrophic lateral sclerosis (ALS)
Parkin-Ubiquitin Proteasomal System pathway
Interleukin-1 processing
Apoptosis Modulation and Signaling
NOD pathway
References
Ref 546056Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006085)
Ref 533644Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6.

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