Drug General Information
Drug ID	D0K6DG
Former ID	DIB006795
Drug Name	ONO-8130
Synonyms	Pollakiuria agent, Ono
Indication	Pollakiuria [ICD10:R35]		Terminated	[547730]
Company	Ono Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Prostaglandin E2 receptor, EP1 subtype	Target Info	Modulator	[531389]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Pathways in cancer
PANTHER Pathway	PI3 kinase pathway
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547730	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018852)
Ref 531389	ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain. 2011 Jun;152(6):1373-81.

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