Drug Information

Drug General Information
Drug ID
D0L1YM
Former ID
DPR000148
Drug Name
McN3377
Synonyms
Fenobam; Fenobamum; Fenobam (TN); Fenobamum [INN-Latin]; McN-3377; NPL-2009; N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea; N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea; 1-(3-chlorophenyl)-3-(3-methyl-5-oxo-4H-imidazol-2-yl)urea; 1-(3-chlorophenyl)-3-[(2e)-1-methyl-4-oxoimidazolidin-2-ylidene]urea
Drug Type
Small molecular drug
Indication Fragile X syndrome [ICD9: 332, 759.83; ICD10:F02.3, G20, Q99.2] Phase 1/2 [522263], [538912]
Therapeutic Class
Psychiatric
Company
McNeil Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C11H11ClN4O2
InChI
InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
InChIKey
DWPQODZAOSWNHB-UHFFFAOYSA-N
PubChem Compound ID
162834
PubChem Substance ID
7698550, 10255018, 12015575, 15368151, 24894721, 26753296, 46237428, 50076506, 57350010, 79662796, 85209784, 85788195, 90341711, 90438823, 103088281, 103088282, 103156738, 103156739, 103546087, 104081432, 113450413, 117595975, 121324203, 121361629, 134221954, 135116692, 135650255, 135651153, 135697547, 136309293, 137133037, 144206177, 144207065, 162023388, 162221725, 162887753, 163134645, 163564796, 164175140, 164814496, 167250227, 170466272, 174006275, 175612574, 177513142, 179150698, 184546104, 198946610, 216088083, 223704488
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator [536166]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 522263ClinicalTrials.gov (NCT00637221) Open Label Study Investigating Safety and Efficacy of NPL2009 50 mg - 150 mg on Prepulse Inhibition Tests and Continuous Performance Tasks, Adults With Fragile X Syndrome. U.S. National Institutes of Health.
Ref 538912(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1434).
Ref 536166Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.

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