Drug Information
Drug General Information | |||||
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Drug ID |
D0L4PY
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Former ID |
DIB016349
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Drug Name |
KB-5492
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Drug Type |
Small molecular drug
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Indication | Peptic ulcer [ICD9: 531-534; ICD10:K25-K27] | Discontinued in Phase 2 | [544799] | ||
Company |
Kanebo KK
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Structure |
Download2D MOL |
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Formula |
C27H34N2O10
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Canonical SMILES |
c1(c(cc(cc1OC)CN1CCN(CC(=O)Oc2ccc(cc2)OC)CC1)OC)OC.C(=O<br />)(/C=C/C(=O)O)O
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CAS Number |
CAS 129200-10-8
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Sigma(1)-type opioid receptor | Target Info | Antagonist | [526642], [532713], [533921] | |
References | |||||
Ref 526642 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | ||||
Ref 532713 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | ||||
Ref 533921 | Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. J Pharmacol Exp Ther. 1994 May;269(2):799-805. |
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