Drug General Information
Drug ID
D0L4PY
Former ID
DIB016349
Drug Name
KB-5492
Drug Type
Small molecular drug
Indication Peptic ulcer [ICD9: 531-534; ICD10:K25-K27] Discontinued in Phase 2 [544799]
Company
Kanebo KK
Structure
Download
2D MOL

3D MOL

Formula
C27H34N2O10
Canonical SMILES
c1(c(cc(cc1OC)CN1CCN(CC(=O)Oc2ccc(cc2)OC)CC1)OC)OC.C(=O<br />)(/C=C/C(=O)O)O
CAS Number
CAS 129200-10-8
PubChem Compound ID
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Antagonist [526642], [532713], [533921]
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 544799Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001141)
Ref 526642Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 533921Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. J Pharmacol Exp Ther. 1994 May;269(2):799-805.

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