Drug Information

Drug General Information
Drug ID
D0LC5O
Former ID
DIB018099
Drug Name
(S)-3,4-DCPG
Synonyms
(S)-3,4-dicarboxylphenylglycine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538883]
Structure
Download
2D MOL
Formula
C10H9NO6
InChI
InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
InChIKey
IJVMOGKBEVRBPP-ZETCQYMHSA-N
PubChem Compound ID
16062593
PubChem Substance ID
26598405, 29947098, 50076268, 91746286, 103383212, 104028806, 135650423, 137132915, 141428199, 162022989, 162494089, 170481115, 233795936, 241182313, 241375350, 248644789, 252450613
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Agonist [525960]
mGlu6 receptor Target Info Agonist [525960]
Metabotropic glutamate receptor 8 Target Info Agonist [525960]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transductionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
GPCRs, Other
References
Ref 538883(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1407).
Ref 525960(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8.

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