Drug Information

Drug General Information
Drug ID
D0M1BJ
Former ID
DNC000858
Drug Name
L-735,821
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539670]
Structure
Download
2D MOL

3D MOL
Formula
C25H19Cl2N3O2
InChI
InChI=1S/C25H19Cl2N3O2/c1-30-21-10-6-5-9-19(21)23(17-7-3-2-4-8-17)29-24(25(30)32)28-22(31)14-12-16-11-13-18(26)15-20(16)27/h2-15,24H,1H3,(H,28,31)/b14-12+/t24-/m1/s1
InChIKey
BYULDQRRUINTAA-SWDTZWKESA-N
CAS Number
CAS 81-54-9
PubChem Compound ID
5282279
PubChem Substance ID
854098, 8616981, 14784833, 15478966, 39315744, 50489386, 103353399, 103956788, 113856834, 135650484, 142572685, 143344402, 223442394, 234105513, 234305713
ChEBI ID
ChEBI:8645
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 1 Target Info Blocker [535746]
KEGG Pathway Adrenergic signaling in cardiomyocytes
Cholinergic synapse
Gastric acid secretion
Pancreatic secretion
Protein digestion and absorption
Vibrio cholerae infection
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Potassium Channels
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
TarBasePathway
References
Ref 539670(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2592).
Ref 535746Molecular determinants of KCNQ1 channel block by a benzodiazepine. Mol Pharmacol. 2003 Jul;64(1):70-7.

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