TTD | Drug: D0MM4X

Drug General Information
Drug ID	D0MM4X
Former ID	DIB009807
Drug Name	MIV-710
Synonyms	MIV-711; MIV-711); Cathepsin K inhibitor (oral, osteoporosis), Medivir
Indication	Bone metastases [ICD9: 198.5; ICD10:C79.51]		Investigative	[543600]
Company	Medivir AB
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=S(=O)(O[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(cc2)c2csc(N3<br />CCN(CC3)C)n2)CC(C)C)[C@H]2[C@@H]1OCC2=O)C
Target and Pathway
Target(s)	Cathepsin K	Target Info	Modulator	[543600]
KEGG Pathway	Lysosome
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Rheumatoid arthritis
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	RANKL Signaling Pathway
	IL2 Signaling Pathway
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Trafficking and processing of endosomal TLR
	MHC class II antigen presentation
WikiPathways	RANKL/RANK Signaling Pathway
WikiPathways	Osteoclast Signaling
References
Ref 543600	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350).
Ref 543600	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350).

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Drug Information