Drug General Information
Drug ID
D0MS3D
Former ID
DIB019714
Drug Name
Delta12-PGJ2
Synonyms
Dddd-PGD2; delta(12)-PGJ2; delta-12-prostaglandin D2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539176]
Structure
Download
2D MOL
Formula
C20H30O4
InChI
InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/b7-4-,18-14+/t16-,17-/m0/s1
InChIKey
TUXFWOHFPFBNEJ-GJGHEGAFSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Agonist [526477]
Prostaglandin D2 receptor Target Info Agonist [534620]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Small Ligand GPCRs
GPCR downstream signaling
References
Ref 539176(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1876).
Ref 526477Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72.
Ref 534620Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24.

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