Drug Information

Drug General Information
Drug ID
D0N2SR
Former ID
DNCL001905
Drug Name
Selexipag
Drug Type
Small molecular drug
Indication Pulmonary arterial hypertension; Thrombosis [ICD9: 416, 437.6, 453, 671.5, 671.9; ICD10:I27.0, I27.2, I80-I82] Approved [523009], [542553]
Company
Actelion Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C26H32N4O4S
InChI
InChI=1S/C26H32N4O4S/c1-20(2)30(16-10-11-17-34-19-24(31)29-35(3,32)33)23-18-27-25(21-12-6-4-7-13-21)26(28-23)22-14-8-5-9-15-22/h4-9,12-15,18,20H,10-11,16-17,19H2,1-3H3,(H,29,31)
InChIKey
QXWZQTURMXZVHJ-UHFFFAOYSA-N
PubChem Compound ID
9913767
PubChem Substance ID
14884195, 24193522, 45985422, 71826069, 75827381, 103543954, 125335605, 127344242, 127344243, 135268706, 135626715, 163125035, 163893551, 198953024, 204362837, 208265357, 223365888, 223872265, 226969886, 241376405, 244974834, 252157218, 252228662, 252480281
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [531815]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 523009ClinicalTrials.gov (NCT01106014) Selexipag (ACT-293987) in Pulmonary Arterial Hypertension, GRIPHON Trial. U.S. National Institutes of Health.
Ref 542553(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7552).
Ref 531815Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J. 2012 Oct;40(4):874-80. Epub 2012 Feb 23.

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