Drug Information
Drug General Information | |||||
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Drug ID |
D0N5LJ
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Former ID |
DNC000782
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Drug Name |
Igmesine
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Drug Type |
Small molecular drug
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Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Phase 2 | [544891] | ||
Structure |
Download2D MOL |
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Formula |
C23H30ClN
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Canonical SMILES |
CCC(CC=CC1=CC=CC=C1)(C2=CC=CC=C2)N(C)CC3CC3.Cl
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InChI |
1S/C23H29N.ClH/c1-3-23(22-14-8-5-9-15-22,24(2)19-21-16-17-21)18-10-13-20-11-6-4-7-12-20;/h4-15,21H,3,16-19H2,1-2H3;1H/b13-10+;
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InChIKey |
SCHQQPAJNUHKSV-RSGUCCNWSA-N
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CAS Number |
CAS 140850-73-3
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Sigma(1)-type opioid receptor | Target Info | Agonist | [535460], [535948], [536208] | |
References | |||||
Ref 535460 | Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels. Eur J Neurosci. 2002 May;15(9):1523-34. | ||||
Ref 535948 | Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs. 2004;18(5):269-84. | ||||
Ref 536208 | Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19. Epub 2006 Mar 21. |
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