Drug Information
Drug General Information | |||||
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Drug ID |
D0O4XW
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Former ID |
DCL000190
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Drug Name |
ONO-4819
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Synonyms |
Rivenprost; AE1-734; ONO-4819CD; ONO-4819.CD; ONO-AE1-734
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Drug Type |
Small molecular drug
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Company |
Novartis
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Structure |
Download2D MOL |
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Formula |
C24H34O6S
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InChI |
InChI=1S/C24H34O6S/c1-29-16-18-6-3-5-17(13-18)14-19(25)8-9-20-21(23(27)15-22(20)26)10-12-31-11-4-7-24(28)30-2/h3,5-6,8-9,13,19-22,25-26H,4,7,10-12,14-16H2,1-2H3/b9-8+/t19-,20-,21-,22-/m1/s1
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InChIKey |
FBQUXLIJKPWCAO-AZIFJQEOSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Prostaglandin E2 receptor, EP4 subtype | Target Info | Agonist | [536219], [536465], [537179] | |
References | |||||
Ref 539230 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1930). | ||||
Ref 547505 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016907) | ||||
Ref 536219 | Effects on improvement of blood flow in the chronically compressed cauda equina: comparison between a selective prostaglandin E receptor (EP4) agonist and a prostaglandin E1 derivate. Spine (Phila Pa1976). 2006 Apr 15;31(8):869-72. | ||||
Ref 536465 | Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation. Bone. 2007 Oct;41(4):543-8. Epub 2007 Jun 29. | ||||
Ref 537179 | Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite- and titanium-coated rough-surfaced implants in ovariectomized rats. J Biomed Mater Res A. 2009 Mar 25. |
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