Drug General Information
Drug ID	D0OW9L
Former ID	DNCL001963
Drug Name	MK-3134
Indication	Dementia [ICD9: 290-294; ICD10:F01-F07]		Phase 1	[522645]
Company	Merck
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Agonist	[531503]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522645	ClinicalTrials.gov (NCT00887601) BOLD Functional Magnetic Resonance Imaging (fMRI) and Cerebral Blood Flow Measurements as Biomarkers for Cognition Enhancing Drugs (3134-006). U.S. National Institutes of Health.
Ref 531503	Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans. Psychopharmacology (Berl). 2011 Dec;218(3):513-24.

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