Drug General Information
Drug ID	D0P1CV
Former ID	DIB004263
Drug Name	PHA-793887
Synonyms	Cyclin-dependent kinase inhibitor (cancer), Nerviano
Drug Type	Small molecular drug
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 1	[531377]
Company	Nerviano Medical Sciences Srl
Structure		Download 2D MOL 3D MOL
Formula	C19H31N5O2
Canonical SMILES	CC1(C)N(C(=O)C2CCN(CC2)C)Cc2c(n[nH]c12)NC(=O)CC(C)C
PubChem Compound ID	46191454
Target and Pathway
Target(s)	Cell division protein kinase 2	Target Info	Inhibitor	[531377]
	Cell division protein kinase 4	Target Info	Inhibitor	[531342]
	Cell division control protein 2 homolog	Target Info	Inhibitor	[531377]
KEGG Pathway	FoxO signaling pathway
	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	PI3K-Akt signaling pathway
	Progesterone-mediated oocyte maturation
	Hepatitis B
	Measles
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Prostate cancer
	Small cell lung cancerhsa04110:Cell cycle
	Tight junction
	T cell receptor signaling pathway
	HTLV-I infection
	Pancreatic cancer
	Glioma
	Melanoma
	Bladder cancer
	Chronic myeloid leukemia
	Small cell lung cancer
	Non-small cell lung cancerhsa04110:Cell cycle
	Gap junction
NetPath Pathway	TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling PathwayNetPath_21:RANKL Signaling Pathway
PANTHER Pathway	p53 pathway
	p53 pathway feedback loops 2
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by PRL
	p73 transcription factor network
	E2F transcription factor network
	ATR signaling pathway
	mTOR signaling pathway
	IL2-mediated signaling events
	FoxO family signaling
	FOXM1 transcription factor network
	BARD1 signaling events
	p53 pathway
	Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Validated targets of C-MYC transcriptional activation
	ATF-2 transcription factor network
	Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
	PLK1 signaling events
	AP-1 transcription factor network
	Retinoic acid receptors-mediated signaling
Reactome	G0 and Early G1
	Activation of ATR in response to replication stress
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	Processing of DNA double-strand break ends
	G2 Phase
	Orc1 removal from chromatin
	Cyclin E associated events during G1/S transition
	Cyclin A/B1 associated events during G2/M transition
	p53-Dependent G1 DNA Damage Response
	Cyclin A:Cdk2-associated events at S phase entry
	Meiotic recombination
	Factors involved in megakaryocyte development and platelet productionR-HSA-2559580:Oxidative Stress Induced Senescence
	Oncogene Induced Senescence
	RMTs methylate histone arginines
	Transcriptional regulation of white adipocyte differentiation
	Ubiquitin-dependent degradation of Cyclin D1
	Cyclin D associated events in G1
	Meiotic recombinationR-HSA-110056:MAPK3 (ERK1) activation
	E2F mediated regulation of DNA replication
	Cyclin B2 mediated events
	Golgi Cisternae Pericentriolar Stack Reorganization
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Phosphorylation of the APC/C
	Phosphorylation of Emi1
	Condensation of Prophase Chromosomes
	MASTL Facilitates Mitotic Progression
	Resolution of Sister Chromatid Cohesion
	Condensation of Prometaphase Chromosomes
	Regulation of PLK1 Activity at G2/M Transition
	Activation of NIMA Kinases NEK9, NEK6, NEK7
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Recruitment of NuMA to mitotic centrosomes
	Depolymerisation of the Nuclear Lamina
	Anchoring of the basal body to the plasma membrane
	MAPK6/MAPK4 signaling
	G1/S-Specific Transcription
	G2/M DNA replication checkpoint
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways	DNA Damage Response
	ID signaling pathway
	DNA Replication
	G1 to S cell cycle control
	M/G1 Transition
	S Phase
	Meiotic Recombination
	Aryl Hydrocarbon Receptor
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Synthesis of DNA
	Regulation of DNA replication
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
	Ovarian Infertility Genes
	PPAR Alpha Pathway
	Bladder Cancer
	Transcriptional Regulation of White Adipocyte Differentiation
	TGF beta Signaling Pathway
	MAP kinase activation in TLR cascade
	RAF/MAP kinase cascade
	Mitotic Prophase
	Mitotic Prometaphase
	BMI1
	Regulation of Microtubule Cytoskeleton
	miRNA Regulation of DNA Damage Response
References
Ref 531377	A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors. Cell Cycle. 2011 Mar 15;10(6):963-70. Epub 2011 Mar 15.
Ref 531342	Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154.
Ref 531377	A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors. Cell Cycle. 2011 Mar 15;10(6):963-70. Epub 2011 Mar 15.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.