Drug General Information
Drug ID	D0P1UC
Former ID	DNC013119
Drug Name	2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528409]
Structure		Download 2D MOL 3D MOL
Formula	C13H12N2O
Canonical SMILES	C1CN=C(N1)C2=CC=C(O2)C3=CC=CC=C3
InChI	1S/C13H12N2O/c1-2-4-10(5-3-1)11-6-7-12(16-11)13-14-8-9-15-13/h1-7H,8-9H2,(H,14,15)
InChIKey	HNPLGLAMYJQFOS-UHFFFAOYSA-N
PubChem Compound ID	16082793
Target and Pathway
Target(s)	Amine oxidase [flavin-containing] A	Target Info	Inhibitor	[528409]
	Amine oxidase [flavin-containing] B	Target Info	Inhibitor	[528409]
BioCyc Pathway	Superpathway of tryptophan utilization
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradation
	Serotonin degradation
	Superpathway of melatonin degradation
	Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
	Tryptophan degradation via tryptamine
KEGG Pathway	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholismhsa00260:Glycine, serine and threonine metabolism
	Alcoholism
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
PathWhiz Pathway	Histidine Metabolism
	Tyrosine Metabolism
	Glycine and Serine Metabolism
Reactome	Norepinephrine Neurotransmitter Release Cycle
WikiPathways	SIDS Susceptibility Pathways
	Biogenic Amine Synthesis
	Oxidative Stress
	Dopamine metabolism
	Phase 1 - Functionalization of compounds
	Neurotransmitter Release Cycle
	Neurotransmitter Clearance In The Synaptic Cleft
	Serotonin Transporter ActivityWP465:Tryptophan metabolism
References
Ref 528409	J Med Chem. 2006 Sep 7;49(18):5578-86.3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor.
Ref 528409	J Med Chem. 2006 Sep 7;49(18):5578-86.3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor.

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