Drug Information
Drug General Information | |||||
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Drug ID |
D0P9EL
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Former ID |
DIB002161
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Drug Name |
AS-601811
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Synonyms |
4,8-Dimethyl-2,3,5,6-tetrahydro-1H-benzo[c]quinolizin-3-one
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Drug Type |
Small molecular drug
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Indication | Acne vulgaris [ICD9: 706.1; ICD10:L70.0] | Discontinued in Phase 1 | [547124] | ||
Structure |
Download2D MOL |
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Formula |
C15H17NO
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Canonical SMILES |
CC1=CC2=C(C=C1)N3CCC(=O)C(=C3CC2)C
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InChI |
1S/C15H17NO/c1-10-3-5-14-12(9-10)4-6-13-11(2)15(17)7-8-16(13)14/h3,5,9H,4,6-8H2,1-2H3
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InChIKey |
SNEPAAKJPPNOQM-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Target Info | Inhibitor | [526428], [547125] | |
KEGG Pathway | Steroid hormone biosynthesis | ||||
NetPath Pathway | IL2 Signaling Pathway | ||||
PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
Reactome | Androgen biosynthesis | ||||
References | |||||
Ref 526428 | Pharmacokinetics and pharmacodynamics of TF-505, a novel nonsteroidal 5alpha-reductase inhibitor, in normal subjects treated with single or multiple doses. Br J Clin Pharmacol. 2002 Sep;54(3):283-94. | ||||
Ref 547125 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013228) |
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