Drug Information

Drug General Information
Drug ID
D0Q0YS
Former ID
DIB020865
Drug Name
rT3
Synonyms
reverse T3; reverse triiodothyronine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539701]
Structure
Download
2D MOL

3D MOL
Formula
C15H12I3NO4
InChI
InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
InChIKey
HZCBWYNLGPIQRK-UHFFFAOYSA-N
PubChem Compound ID
22069
PubChem Substance ID
4776857, 8144291, 8166261, 15385647, 24899878, 29289415, 50125932, 57331066, 77382764, 103408943, 104355034, 124893719, 126411015, 128133936, 135650897, 137125084, 142950801, 162135182, 163059360, 163638934, 164799167, 226753740, 242073660, 250133371
Target and Pathway
Target(s) Thyroid hormone receptor alpha Target Info Agonist [531482]
Thyroid hormone receptor beta-1 Target Info Agonist [531482]
KEGG Pathway Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Endochondral Ossification
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Nuclear Receptors
References
Ref 539701(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2636).
Ref 531482Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34.

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