Drug General Information
Drug ID	D0Q3DI
Former ID	DNC013398
Drug Name	3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529101]
Structure		Download 2D MOL 3D MOL
Formula	C16H11N3O
Canonical SMILES	COC1=CC(=CC(=C1)C2=CC3=C(C=CC=N3)N=C2)C#N
InChI	1S/C16H11N3O/c1-20-14-6-11(9-17)5-12(7-14)13-8-16-15(19-10-13)3-2-4-18-16/h2-8,10H,1H3
InChIKey	KPRNNBVYUUWBLA-UHFFFAOYSA-N
PubChem Compound ID	44434733
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[529101]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529101	Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
Ref 529101	Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.

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