Drug Information

Drug General Information
Drug ID
D0R2TM
Former ID
DNC003686
Drug Name
BALANOL
Drug Type
Small molecular drug
Indication Discovery agent Terminated [542983], [545589]
Structure
Download
2D MOL

3D MOL
Formula
C28H26N2O10
InChI
InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
InChIKey
XYUFCXJZFZPEJD-XMSQKQJNSA-N
PubChem Compound ID
5287736
PubChem Substance ID
7886051, 8032894, 11041327, 14763739, 14837260, 39320290, 48110651, 48334706, 50715651, 87544375, 87544377, 103252142, 113870323, 118043174, 127319915, 127319916, 127319917, 127319918, 127319919, 127319920, 127319921, 127319922, 134340891, 137252596, 162255238, 179247016, 226443673, 241113714, 249565822, 252345375
Target and Pathway
Target(s) mRNA of PKC-epsilon Target Info Inhibitor [551285]
Casein kinase II, alpha chain Target Info Inhibitor [534297]
mRNA of PKC-zeta Target Info Inhibitor [551285]
mRNA of PKC-delta Target Info Inhibitor [551285]
Protein kinase A Target Info Inhibitor [527710]
CAMP-dependent protein kinase type II-beta regulatory chain Target Info Inhibitor [527710]
Protein kinase C gamma type Target Info Inhibitor [551285]
mRNA of human PKC-eta Target Info Inhibitor [551285]
mRNA of PKA Catalytic Subunit C-alpha Target Info Inhibitor [527710]
Protein kinase C, alpha type Target Info Inhibitor [551285]
Protein kinase C, beta type Target Info Inhibitor [551285]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Vascular smooth muscle contraction
Tight junction
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Inflammatory mediator regulation of TRP channels
Type II diabetes mellitus
MicroRNAs in cancerhsa03008:Ribosome biogenesis in eukaryotes
NF-kappa B signaling pathway
Wnt signaling pathway
Adherens junction
Measles
Herpes simplex infection
Epstein-Barr virus infectionhsa04015:Rap1 signaling pathway
Chemokine signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Platelet activation
Insulin signaling pathway
Type II diabetes mellitushsa04062:Chemokine signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Type II diabetes mellitushsa04210:Apoptosis
Insulin signaling pathwayhsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04270:Vascular smooth muscle contraction
Inflammatory mediator regulation of TRP channelshsa04010:MAPK signaling pathway
cAMP signaling pathway
Oocyte meiosis
Apoptosis
Adrenergic signaling in cardiomyocytes
Hedgehog signaling pathway
Olfactory transduction
Taste transduction
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Vasopressin-regulated water reabsorption
Bile secretion
Parkinson's disease
Prion diseases
Cocaine addiction
Alcoholism
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Dilated cardiomyopathyhsa04010:MAPK signaling pathway
Pathogenic Escherichia coli infection
Influenza A
Choline metabolism in cancerhsa04010:MAPK signaling pathway
B cell receptor signaling pathway
Carbohydrate digestion and absorption
Leishmaniasis
Choline metabolism in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
B cell activation
CCKR signaling map STP00019:Endothelin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Transcription regulation by bZIP transcription factor
5HT1 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Histamine H2 receptor mediated signaling pathway
GABA-B receptor II signaling
Dopamine receptor mediated signaling pathway
Enkephalin releaseP00002:Alpha adrenergic receptor signaling pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
Metabotropic glutamate receptor group I pathway
Enkephalin release
Nicotine pharmacodynamics pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
PDGF signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map ST
Pathway Interaction Database Endothelins
LPA receptor mediated events
TCR signaling in na&#xef
LPA4-mediated signaling events
CDC42 signaling events
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
PDGFR-beta signaling pathway
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
BCR signaling pathway
Atypical NF-kappaB pathway
DNA-PK pathway in nonhomologous end joining
Presenilin action in Notch and Wnt signaling
E-cadherin signaling in the nascent adherens junction
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-alpha signaling pathway
Signaling mediated by p38-alpha and p38-beta
Alpha-synuclein signalingrhoa_pathway:RhoA signaling pathway
Insulin Pathway
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL1-mediated signaling events
CXCR4-mediated signaling events
IGF1 pathway
TNF receptor signaling pathway
IL2 signaling events mediated by PI3K
Ceramide signaling pathway
p75(NTR)-mediated signaling
amb2 Integrin signaling
ErbB1 downstream signaling
Neurotrophic factor-mediated Trk receptor signaling
Nephrin/Neph1 signaling in the kidney podocyte
Insulin-mediated glucose transport
Regulation of Ras family activationendothelinpathway:Endothelins
IFN-gamma pathway
Syndecan-4-mediated signaling events
IL6-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
Syndecan-2-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Alpha-synuclein signalingendothelinpathway:Endothelins
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
Role of Calcineurin-dependent NFAT signaling in lymphocytesgmcsf_pathway:GMCSF-mediated signaling events
Signaling events regulated by Ret tyrosine kinase
LKB1 signaling events
SHP2 signaling
Signaling events mediated by HDAC Class I
Glucocorticoid receptor regulatory network
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
Syndecan-1-mediated signaling events
VEGFR1 specific signals
Calcium signaling in the CD4+ TCR pathway
Aurora A signaling
Class I PI3K signaling events mediated by Akt
Alpha4 beta1 integrin signaling eventsendothelinpathway:Endothelins
Canonical NF-kappaB pathway
mTOR signaling pathway
Ras signaling in the CD4+ TCR pathway
ATF-2 transcription factor network
a6b1 and a6b4 Integrin signaling
Fc-epsilon receptor I signaling in mast cells
JNK signaling in the CD4+ TCR pathway
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000564:Muscle/Heart ContractionPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptor
Reactome Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling eventsR-HSA-2514853:Condensation of Prometaphase ChromosomesR-HSA-114604:GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferationR-HSA-111465:Apoptotic cleavage of cellular proteins
Calmodulin induced events
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-163615:PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Factors involved in megakaryocyte development and platelet productionR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+R-HSA-114508:Effects of PIP2 hydrolysis
G alpha (z) signalling eventsR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
PKA activation
Regulation of insulin secretion
VEGFA-VEGFR2 Pathway
Interleukin-3, 5 and GM-CSF signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
Gluconeogenesis
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Depolymerisation of the Nuclear Lamina
Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Response to elevated platelet cytosolic Ca2+
WikiPathways Hypothetical Network for Drug Addiction
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Oncostatin M Signaling Pathway
miRs in Muscle Cell Differentiation
GPCR downstream signaling
Effects of PIP2 hydrolysis
Physiological and Pathological Hypertrophy of the HeartWP2652:Mitotic Prometaphase
BDNF signaling pathway
TNF alpha Signaling Pathway
L1CAM interactionsWP536:Calcium Regulation in the Cardiac Cell
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
Signaling by TGF-beta Receptor Complex
Allograft Rejection
AGE/RAGE pathway
Signaling Pathways in Glioblastoma
IL-1 signaling pathway
GPVI-mediated activation cascade
Type II diabetes mellitusWP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
IL-6 signaling pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
DAG and IP3 signaling
Alpha 6 Beta 4 signaling pathway
Corticotropin-releasing hormone
B Cell Receptor Signaling Pathway
Opioid Signalling
Apoptotic execution phase
Type II diabetes mellitusWP706:SIDS Susceptibility Pathways
Regulation of Water Balance by Renal Aquaporins
Mitotic G2-G2/M phases
Integration of energy metabolism
Factors involved in megakaryocyte development and platelet productionWP536:Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway Netpath
Response to elevated platelet cytosolic Ca2+WP536:Calcium Regulation in the Cardiac Cell
Effects of PIP2 hydrolysisWP706:SIDS Susceptibility Pathways
Endochondral Ossification
IL-3 Signaling Pathway
Mesodermal Commitment Pathway
Human Complement System
Dopamine metabolism
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
SREBP signalling
Factors involved in megakaryocyte development and platelet production
Nicotine Activity on Dopaminergic NeuronsWP673:ErbB Signaling Pathway
Kit receptor signaling pathway
Transcriptional activation by NRF2
Cardiac Hypertrophic Response
Syndecan interactions
Signaling by SCF-KIT
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Endothelin Pathways
Response to elevated platelet cytosolic Ca2+
TOR SignalingWP536:Calcium Regulation in the Cardiac Cell
Signaling by the B Cell Receptor (BCR)
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
References
Ref 542983(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8142).
Ref 545589Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003814)
Ref 527710J Med Chem. 2005 Sep 8;48(18):5613-38.Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.
Ref 534297J Med Chem. 1996 Dec 20;39(26):5215-27.Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.
Ref 551285Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).

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