Drug General Information
Drug ID
D0R4TA
Former ID
DIB021041
Drug Name
tetronothiodin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526869]
Structure
Download
2D MOL
Formula
C31H38O8S
InChI
InChI=1S/C31H38O8S/c1-17-10-8-9-13-21(32)12-7-5-4-6-11-20-14-18(2)19(3)15-31(20)28(35)24(30(38)39-31)25(33)22-16-40-27(23(17)22)26(34)29(36)37/h4-9,14,17,19-23,27,32,38H,10-13,15-16H2,1-3H3,(H,36,37)/b6-4+,7-5+,9-8+
InChIKey
RMYJUZDMOJDYES-SFYXYOTASA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Antagonist [533945]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 526869Tetronothiodin, a novel CCKB receptor ligand, antagonizes cholecystokinin-induced Ca2+ mobilization in a pituitary cell line. Eur J Pharmacol. 1992 Oct 6;221(1):99-105.
Ref 533945Species specificity of pharmacological characteristics of CCK-B receptors. Neurosci Lett. 1993 Aug 6;158(1):1-4.

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