Drug Information
| Drug General Information | |||||
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| Drug ID |
D0S5ZJ
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| Former ID |
DIB009757
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| Drug Name |
SERGOLEXOLE MALEATE
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| Synonyms |
LY-281067; Sergolexole maleate < Rec INNM; [trans-(8beta)]-1-Isopropyl-6-methylergoline-8-carboxylic acid 4-methoxycyclohexyl ester maleate; (9S)-4-Isopropyl-7-methyl-4,6,6abeta,7,8,9,10,10aalpha-octahydroindolo[3,4-fg]quinoline-9beta-carboxylic acid trans-4-methoxycyclohexyl ester maleate
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD9: 346; ICD10:G43] | Discontinued in Phase 2 | [544716] | ||
| Structure |
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Download2D MOL |
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| Formula |
C30H40N2O7
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| Canonical SMILES |
COC1CCC(CC1)OC(=O)[C@@H]2C[C@H]3[C@@H](Cc4cn(C(C)C)c5cc<br />cc3c45)N(C)C2.OC(=O)\\C=C/C(=O)O
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| InChI |
1S/C26H36N2O3.C4H4O4/c1-16(2)28-15-17-13-24-22(21-6-5-7-23(28)25(17)21)12-18(14-27(24)3)26(29)31-20-10-8-19(30-4)9-11-20;5-3(6)1-2-4(7)8/h5-7,15-16,18-20,22,24H,8-14H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t18-,19?,20?,22-,24-;/m1./s1
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| InChIKey |
AWRYUNKJBYLYFR-VRUJKGOYSA-N
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| CAS Number |
CAS 108674-87-9
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2A receptor | Target Info | Antagonist | [526792], [533252] | |
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| References | |||||
| Ref 526792 | Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59. | ||||
| Ref 533252 | 5-Hydroxytryptamine2 receptor antagonist activity of the acid metabolite (1-isopropyl dihydrolysergic acid) of the ergoline ester, sergolexole (LY281067). J Pharmacol Exp Ther. 1989 Dec;251(3):1006-11. | ||||
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