Drug General Information
Drug ID	D0SN6R
Former ID	DNC009137
Drug Name	(+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530012]
Structure		Download 2D MOL 3D MOL
Formula	C15H17NO
Canonical SMILES	C1CNCC1COC2=CC3=CC=CC=C3C=C2
InChI	1S/C15H17NO/c1-2-4-14-9-15(6-5-13(14)3-1)17-11-12-7-8-16-10-12/h1-6,9,12,16H,7-8,10-11H2
InChIKey	FXQBHPKGRGPIKE-UHFFFAOYSA-N
PubChem Compound ID	44592197
Target and Pathway
Target(s)	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[530012]
	Sodium-dependent serotonin transporter	Target Info	Inhibitor	[530012]
	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[530012]
KEGG Pathway	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholismhsa04726:Serotonergic synapse
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
	5HT2 type receptor mediated signaling pathway
	5HT3 type receptor mediated signaling pathway
	5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
	SIDS Susceptibility Pathways
	Synaptic Vesicle Pathway
	Serotonin Transporter ActivityWP727:Monoamine Transport
References
Ref 530012	Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. Epub 2009 Feb 20.Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.
Ref 530012	Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. Epub 2009 Feb 20.Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.

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