Drug Information
Drug General Information | |||||
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Drug ID |
D0T1FJ
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Former ID |
DNC014138
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Drug Name |
4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [530434] | ||
Structure |
Download2D MOL |
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Formula |
C17H15NO3
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Canonical SMILES |
C1=CC=C(C=C1)COC2=CC3=C(C=C2)C(=CC(=O)O3)CN
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InChI |
1S/C17H15NO3/c18-10-13-8-17(19)21-16-9-14(6-7-15(13)16)20-11-12-4-2-1-3-5-12/h1-9H,10-11,18H2
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InChIKey |
XCWHFSADYQMGEA-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Amine oxidase [flavin-containing] A | Target Info | Inhibitor | [530434] | |
Amine oxidase [flavin-containing] B | Target Info | Inhibitor | [530434] | ||
BioCyc Pathway | Superpathway of tryptophan utilization | ||||
Dopamine degradation | |||||
Putrescine degradation III | |||||
Noradrenaline and adrenaline degradation | |||||
Serotonin degradation | |||||
Superpathway of melatonin degradation | |||||
Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization | |||||
Tryptophan degradation via tryptamine | |||||
KEGG Pathway | Glycine, serine and threonine metabolism | ||||
Arginine and proline metabolism | |||||
Histidine metabolism | |||||
Tyrosine metabolism | |||||
Phenylalanine metabolism | |||||
Tryptophan metabolism | |||||
Drug metabolism - cytochrome P450 | |||||
Metabolic pathways | |||||
Serotonergic synapse | |||||
Dopaminergic synapse | |||||
Cocaine addiction | |||||
Amphetamine addiction | |||||
Alcoholismhsa00260:Glycine, serine and threonine metabolism | |||||
Alcoholism | |||||
NetPath Pathway | IL4 Signaling Pathway | ||||
Pathway Interaction Database | Alpha-synuclein signaling | ||||
References | |||||
Ref 530434 | J Med Chem. 2009 Nov 12;52(21):6685-706.Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor. | ||||
Ref 530434 | J Med Chem. 2009 Nov 12;52(21):6685-706.Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor. |
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