Drug Information
Drug General Information | |||||
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Drug ID |
D0T3LF
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Former ID |
DAP000572
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Drug Name |
Dextroamphetamine
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Synonyms |
Amsustain; Benzedrine; Dephadren; Desamfetamina; Dexacaps; Dexadrine; Dexamfetamina; Dexamfetamine; Dexamfetaminum; Dexamphetamine; Dexamphetaminum; Dexanfetamina; Dexedrine; Dexidrine; Isoamycin; Propisamine; Psychedrine; Raphetamine; Rhinalator; Simpatedrin; Sympamin; Sympamine; Sympatedrine; Weckamine; Desamfetamina [DCIT]; Dexedrine Spansule; Dextroamphetamine [USAN]; Dextroamphetamine resin complex; D-AM; D-Amphetamine; Dexamfetamina [INN-Spanish]; Dexamfetamine (INN); Dexamfetaminum [INN-Latin]; Dexamphetaminum [INN-Latin]; Dexanfetamina [INN-Spanish]; Dexedrine (TN); Dextro-Amphetamine; Dextro-Amphetamine Sulfate; Dextroamphetamine (USAN); Dextrostat (TN); Dl-Amphetamine; Dl-Benzedrine; Fenylo-izopropylaminyl; Beta-phenyl-isopropylamine; D-alpha-methylphenethylamine; Alpha-Methylphenethylamine, d-form; D-(S)-Amphetamine; S(+)-Amphetamine; D-(+)-Amphetamine; D-1-Phenyl-2-aminopropan; D-1-Phenyl-2-aminopropan [German]; D-1-Phenyl-2-aminopropane; D-2-Amino-1-phenylpropane; Dl-1-Phenyl-2-aminopropane; Benzeneethanamine, alpha-methyl-, (aS)-(9CI); Phenethylamine, alpha-methyl-, (+)-(8CI); (+)-(S)-Amphetamine; (+)-Amphetamine; (+)-Phenaminum; (+)-alpha-Methylphenethylamine; (+)-alpha-Methylphenylethylamine; (+/-)-Benzedrine; (+/-)-Desoxynorephedrine; (+/-)-beta-Phenylisopropylamine; (2S)-(+)-Amphetamine; (2S)-1-phenylpropan-2-amine; (S)-(+)-Amphetamine; (S)-(+)-beta-Phenylisopropylamine; (S)-1-Phenyl-2-aminopropane; (S)-1-Phenyl-2-propanamine; (S)-1-Phenyl-2-propylamine; (S)-Amphetamine; (S)-alpha-Methylphenethylamine; (S)-alpha-Phenylethylamine; (S)-alpha-methylbenzeneethanamine; (alphaS)-alpha-methylbenzeneethanamine
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Drug Type |
Small molecular drug
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Indication | Attention deficit hyperactivity disorder; Narcolepsy [ICD10:F90, G47.4] | Approved | [551871] | ||
Therapeutic Class |
Central Nervous System Stimulants
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Company |
GlaxoSmithKline
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Structure |
Download2D MOL |
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Formula |
C9H13N
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Canonical SMILES |
CC(CC1=CC=CC=C1)N
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InChI |
1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1
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InChIKey |
KWTSXDURSIMDCE-QMMMGPOBSA-N
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CAS Number |
CAS 51-64-9
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PubChem Compound ID | |||||
PubChem Substance ID |
10086, 841177, 8153594, 10318924, 15170721, 17397829, 29224859, 30896359, 46506252, 47359952, 47954515, 48415867, 50004613, 50071310, 50113060, 57322985, 77830612, 96099848, 103185157, 103933285, 104310370, 127272464, 127272465, 127329738, 127329739, 127329740, 127329741, 127329742, 127329743, 127329744, 127329745, 127329746, 128273812, 128445969, 134337863, 134338391, 134338667, 134972590, 135650979, 137001216, 142361370, 160963530, 170475110, 170506196, 175266841, 175269378, 175444077, 179116645, 184585369, 223826584
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ChEBI ID |
ChEBI:4469
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SuperDrug ATC ID |
N06BA02
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SuperDrug CAS ID |
cas=000051649
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Target and Pathway | |||||
Target(s) | Trace amine-associated receptor-1 | Target Info | Modulator | [526471], [526676], [532175], [532852] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Reactome | G alpha (s) signalling events | ||||
References | |||||
Ref 526471 | Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8. | ||||
Ref 526676 | Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21. | ||||
Ref 532175 | Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8. | ||||
Ref 532852 | Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507. |
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