Drug General Information
Drug ID	D0T6SC
Former ID	DIB020545
Drug Name	N-methylhistamine
Synonyms	1-methylhistamine; tele-methylhistamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538756]
Structure		Download 2D MOL
Formula	C6H11N3
InChI	InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3
InChIKey	FHQDWPCFSJMNCT-UHFFFAOYSA-N
PubChem Compound ID	3614
PubChem Substance ID	7548, 111689, 5065180, 8145147, 8152280, 11111463, 15119885, 29222739, 47216971, 47810959, 48035337, 49979067, 50111134, 57321898, 76044006, 85209553, 90341373, 92298650, 103101425, 103173361, 104304019, 117477866, 117520177, 124749973, 124880726, 125676784, 126523660, 127848575, 132633463, 134223963, 134978378, 135650397, 135650399, 137099432, 141970489, 162860538, 164793246, 179235711, 198946623, 223789805, 226554786, 229808748, 249963036
Target and Pathway
Target(s)	Histamine H4 receptor	Target Info	Agonist	[526144]
	Histamine H3 receptor	Target Info	Agonist	[535111]
KEGG Pathway	Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
	G alpha (i) signalling events
WikiPathways	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP727:Monoamine Transport
	GPCRs, Class A Rhodopsin-like
References
Ref 538756	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1242).
Ref 526144	Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30.
Ref 535111	Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.

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