Drug Information

Drug General Information
Drug ID
D0U1DU
Former ID
DIB003224
Drug Name
NVX-207
Synonyms
Sterol analog (anticancer), Novelix
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543451]
Company
University of Southern California
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[C@@]12([C@]3([C@@H]([C@@]4([C@H](C([C@H](CC4)OC(=O)C)(<br />C)C)CC3)C)CC[C@@H]1[C@@H]1[C@@](C(=O)OCC(CO)(CO)N)(CC2)<br />CC[C@H]1C(=C)C)C)C
Target and Pathway
Target(s) Caspase-9 Target Info Modulator [543451]
KEGG Pathway p53 signaling pathway
PI3K-Akt signaling pathway
Apoptosis
VEGF signaling pathway
Thyroid hormone signaling pathway
Alzheimer's disease
Parkinson's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Legionellosis
Toxoplasmosis
Tuberculosis
Hepatitis B
Influenza A
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Small cell lung cancer
Non-small cell lung cancer
Viral myocarditis
NetPath Pathway IL2 Signaling Pathway
FSH Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Angiogenesis
Apoptosis signaling pathway
FAS signaling pathway
PI3 kinase pathway
VEGF signaling pathway
Pathway Interaction Database p75(NTR)-mediated signaling
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Class I PI3K signaling events mediated by Akt
Reactome SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways DNA Damage Response
Apoptosis Modulation by HSP70
FAS pathway and Stress induction of HSP regulation
PIP3 activates AKT signaling
Apoptosis
Amyotrophic lateral sclerosis (ALS)
Integrated Pancreatic Cancer Pathway
Parkinsons Disease Pathway
Corticotropin-releasing hormone
Allograft Rejection
AGE/RAGE pathway
TNF alpha Signaling Pathway
Prostate Cancer
Alzheimers Disease
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Regulation of Apoptosis
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
miRNA Regulation of DNA Damage Response
NOD pathway
References
Ref 543451(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1625).
Ref 543451(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1625).

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