TTD | Drug: D0U5JP

Drug General Information
Drug ID	D0U5JP
Former ID	DCL000880
Drug Name	MEM-3454
Drug Type	Small molecular drug
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Phase 2	[536463]
Company	Memory Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C21H20FN2O4S-
Canonical SMILES	C1CC2=C(CC1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O<br />)[O-]
InChI	1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/p-1/t15-/m1/s1
InChIKey	LDXDSHIEDAPSSA-OAHLLOKOSA-M
PubChem Compound ID	22849387
PubChem Substance ID	40875157, 71821370, 134339335
Target and Pathway
Target(s)	Neuronal acetylcholine receptor protein, alpha-7 chain	Target Info	Antagonist	[536463]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Nicotine addiction
	Chemical carcinogenesis
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
PANTHER Pathway	Nicotinic acetylcholine receptor signaling pathway
Reactome	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways	SIDS Susceptibility Pathways
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 536463	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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Drug Information