Drug General Information
Drug ID	D0U6KH
Former ID	DCL000527
Drug Name	Figitumumab
Drug Type	Monoclonal antibody
Indication	Malignant adrenal gland cancer [ICD10:C74.0]		Discontinued in Phase 1	[547948]
Company	Pfizer
Structure		Download 2D MOL 3D MOL
Formula	C44H68O13
PubChem Compound ID	6917781
Target and Pathway
Target(s)	Insulin-like growth factor I receptor	Target Info	Inhibitor	[549974], [550522]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Oocyte meiosis
	Endocytosis
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Focal adhesion
	Adherens junction
	Signaling pathways regulating pluripotency of stem cells
	Long-term depression
	Ovarian steroidogenesis
	Progesterone-mediated oocyte maturation
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	Glioma
	Prostate cancer
	Melanoma
PANTHER Pathway	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascade
Pathway Interaction Database	Plasma membrane estrogen receptor signaling
	SHP2 signaling
	IGF1 pathway
	Posttranslational regulation of adherens junction stability and dissassembly
	Integrins in angiogenesis
	Stabilization and expansion of the E-cadherin adherens junction
Reactome	IRS-related events triggered by IGF1R
	SHC-related events triggered by IGF1R
WikiPathways	Senescence and Autophagy in Cancer
	Insulin Signaling
	Endochondral Ossification
	Focal Adhesion
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	Apoptosis
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 547948	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020634)
Ref 549974	Pfizer. Product Development Pipeline. March 31 2009.
Ref 550522	National Cancer Institute. NCI Drug Dictionary. 2009 (CdrID=456793)

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