Drug General Information
Drug ID
D0U7WF
Former ID
DIB018489
Drug Name
16,16-dimethyl-PGE2
Synonyms
16,16-dimethylprostaglandin E2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539226]
Structure
Download
2D MOL
Formula
C22H36O5
InChI
InChI=1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1
InChIKey
QAOBBBBDJSWHMU-WMBBNPMCSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534478]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [534478]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [534478]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Pathways in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
Vitamin D Receptor Pathway
GPCR downstream signaling
References
Ref 539226(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1926).
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

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