Drug Information

Drug General Information
Drug ID
D0U8AR
Former ID
DIB015763
Drug Name
DMP-851
Synonyms
XQ-443; (4R,5S,6S,7R)-1-(3-Amino-1H-indazol-5-ylmethyl)-4,7-dibenzyl-3-butyl-5,6-dihydroxyperhydro-1,3-diazepin-2-one
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 1 [546493]
Structure
Download
2D MOL

3D MOL
Formula
C31H37N5O3
Canonical SMILES
CCCCN1[C@H](Cc2ccccc2)[C@H](O)[C@@H](O)[C@@H](Cc3ccccc3<br />)N(Cc4ccc5[nH]nc(N)c5c4)C1=O
InChI
1S/C31H37N5O3/c1-2-3-16-35-26(18-21-10-6-4-7-11-21)28(37)29(38)27(19-22-12-8-5-9-13-22)36(31(35)39)20-23-14-15-25-24(17-23)30(32)34-33-25/h4-15,17,26-29,37-38H,2-3,16,18-20H2,1H3,(H3,32,33,34)/t26-,27-,28+,29+/m1/s1
InChIKey
CGEJBZXGNPASAG-GKQHHHCTSA-N
PubChem Compound ID
470551
Target and Pathway
Target(s) HIV protease Target Info Inhibitor [534751], [551871]
References
Ref 546493Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008536)
Ref 534751Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol. 1998 Oct;5(10):597-608.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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