Drug Information

Drug General Information
Drug ID
D0V4BR
Former ID
DNC005272
Drug Name
4-Chloro-N-(2-methyl-benzoyl)-benzenesulfonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527245]
Structure
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2D MOL

3D MOL
Formula
C14H12ClNO3S
Canonical SMILES
CC1=CC=CC=C1C(=O)NS(=O)(=O)C2=CC=C(C=C2)Cl
InChI
1S/C14H12ClNO3S/c1-10-4-2-3-5-13(10)14(17)16-20(18,19)12-8-6-11(15)7-9-12/h2-9H,1H3,(H,16,17)
InChIKey
JQSONZDJELNSLQ-UHFFFAOYSA-N
PubChem Compound ID
11266872
Target and Pathway
Target(s) mRNA of VEGFR1 Target Info Inhibitor [527245]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [527245]
Vascular endothelial growth factor receptor 3 Target Info Inhibitor [527245]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
VEGF signaling pathway
Proteoglycans in cancerhsa04014:Ras signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkvegf_vegfr_pathway:VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endothelium
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
AngiogenesisWP1919:Signaling by VEGF
References
Ref 527245J Med Chem. 2004 Oct 21;47(22):5367-80.Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.
Ref 527245J Med Chem. 2004 Oct 21;47(22):5367-80.Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.

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