Drug Information

Drug General Information
Drug ID
D0W2FM
Former ID
DNC010748
Drug Name
(2'Z,3'E)-5-Fluoro-5'-methyl-indirubin-3'-oxime
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530823]
Structure
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2D MOL

3D MOL
Formula
C17H12FN3O2
Canonical SMILES
CC1=CC2=C(C=C1)NC(=C2NO)C3=C4C=C(C=CC4=NC3=O)F
InChI
1S/C17H12FN3O2/c1-8-2-4-13-11(6-8)15(21-23)16(19-13)14-10-7-9(18)3-5-12(10)20-17(14)22/h2-7,19,21,23H,1H3
InChIKey
AOHOEWSGVMNRFC-UHFFFAOYSA-N
PubChem Compound ID
46222698
Target and Pathway
Target(s) Cell division protein kinase 2 Target Info Inhibitor [530823]
G1/S-specific cyclin E1 Target Info Inhibitor [530823]
KEGG Pathway FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis B
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancerhsa04110:Cell cycle
MicroRNAs in cancer
Small cell lung cancer
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway p53 pathway
p53 pathway feedback loops 2P00013:Cell cycle
Parkinson disease
p53 pathway feedback loops 2
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by PRL
p73 transcription factor network
E2F transcription factor network
ATR signaling pathway
mTOR signaling pathway
IL2-mediated signaling events
FoxO family signaling
FOXM1 transcription factor network
BARD1 signaling events
p53 pathway
Regulation of retinoblastoma proteinprlsignalingeventspathway:Signaling events mediated by PRL
PLK3 signaling events
Regulation of retinoblastoma protein
Reactome G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
G2 Phase
Orc1 removal from chromatin
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet productionR-HSA-113510:E2F mediated regulation of DNA replication
G1/S-Specific Transcription
WikiPathways DNA Damage Response
ID signaling pathway
DNA Replication
G1 to S cell cycle control
M/G1 Transition
S Phase
Meiotic Recombination
Aryl Hydrocarbon Receptor
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Synthesis of DNA
Regulation of DNA replication
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Factors involved in megakaryocyte development and platelet production
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
Parkinsons Disease Pathway
Parkin-Ubiquitin Proteasomal System pathway
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
Androgen receptor signaling pathway
References
Ref 530823J Med Chem. 2010 May 13;53(9):3696-706.5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity.
Ref 530823J Med Chem. 2010 May 13;53(9):3696-706.5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity.

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