Drug Information

Drug General Information
Drug ID
D0W9VB
Former ID
DAP001133
Drug Name
Diphenidol
Synonyms
Avomol; Defenidol; Difenidol; Difenidolo; Difenidolum; Nometic; Vontrol; Difenidol HCl; Difenidolo [DCIT]; SKF 478; Difenidolum [INN-Latin]; Diphenidol [USAN:BAN]; SK-478; Diphenidol (USAN/INN); SK&F-478; Alpha,alpha-Diphenyl-1-piperidinebutanol; Diphenyl(3-(1-piperidyl)propyl)carbinol; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol hydrochloride
Drug Type
Small molecular drug
Indication Nausea; Vomiting; Emesis [ICD9: 787, 787.0; ICD10:R11] Approved [538470], [542172], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C21H27NO
InChI
InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
InChIKey
OGAKLTJNUQRZJU-UHFFFAOYSA-N
CAS Number
CAS 972-02-1
PubChem Compound ID
3055
PubChem Substance ID
9175, 5635332, 8151944, 10538868, 11112531, 11466280, 11467400, 11486019, 15420107, 17397943, 29222201, 46506486, 47291279, 47810922, 47810923, 48334667, 48415910, 49698405, 50015356, 50100475, 56464134, 57321583, 80516491, 85787519, 92251441, 92720233, 103243329, 103816013, 104302396, 106222940, 114916617, 117612528, 118313878, 124882438, 125360426, 126620156, 126667668, 127339718, 127339719, 127339720, 128803775, 134224133, 134338378, 134981108, 137029102, 138363295, 144206624, 160964563, 164826978, 165719084
ChEBI ID
ChEBI:4638
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M4 Target Info Antagonist [536678]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538470FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016033.
Ref 542172(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7163).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536678Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. Epub 2008 Mar 23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.