Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0WF2C
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| Former ID |
DNC006000
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| Drug Name |
Bbs-Arg-(D-Pip)-Gly-S-(GS)9-Gly-Hir
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| Indication | Discovery agent | Investigative | [527780] | ||
| Structure |
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Download2D MOL |
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| Formula |
C138H206N38O59S
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| Canonical SMILES |
CCC(C)C(C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C<br />(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)<br />C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC3=CC<br />=CC=C3)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C<br />(CO)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(<br />CO)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(C<br />O)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C4CC<br />CCN4C(=O)C(CCCN=C(N)N)NS(=O)(=O)C5=CC=C(C=C5)C(C)(C)C
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| InChI |
1S/C138H206N38O59S/c1-8-68(4)113(135(231)176-41-15-20-95(176)133(229)168-76(32-37-110(204)205)125(221)165-75(31-36-109(202)203)126(222)171-82(44-70-21-25-72(187)26-22-70)130(226)170-80(42-67(2)3)128(224)169-79(136(232)233)29-34-96(139)188)173-127(223)77(33-38-111(206)207)166-124(220)74(30-35-108(200)201)167-129(225)81(43-69-16-10-9-11-17-69)172-131(227)83(45-112(208)209)154-97(189)46-143-114(210)84(57-177)155-98(190)47-144-115(211)85(58-178)156-99(191)48-145-116(212)86(59-179)157-100(192)49-146-117(213)87(60-180)158-101(193)50-147-118(214)88(61-181)159-102(194)51-148-119(215)89(62-182)160-103(195)52-149-120(216)90(63-183)161-104(196)53-150-121(217)91(64-184)162-105(197)54-151-122(218)92(65-185)163-106(198)55-152-123(219)93(66-186)164-107(199)56-153-132(228)94-19-12-13-40-175(94)134(230)78(18-14-39-142-137(140)141)174-236(234,235)73-27-23-71(24-28-73)138(5,6)7/h9-11,16-17,21-28,67-68,74-95,113,174,177-187H,8,12-15,18-20,29-66H2,1-7H3,(H2,139,188)(H,143,210)(H,144,211)(H,145,212)(H,146,213)(H,147,214)(H,148,215)(H,149,216)(H,150,217)(H,151,218)(H,152,219)(H,153,228)(H,154,189)(H,155,190)(H,156,191)(H,157,192)(H,158,193)(H,159,194)(H,160,195)(H,161,196)(H,162,197)(H,163,198)(H,164,199)(H,165,221)(H,166,220)(H,167,225)(H,168,229)(H,169,224)(H,170,226)(H,171,222)(H,172,227)(H,173,223)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,232,233)(H4,140,141,142)/t68-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94?,95-,113-/m0/s1
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| InChIKey |
UFWRMLMUWLGVGM-PIMIKREUSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Coagulation factor IIa | Target Info | Inhibitor | [527780] | |
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Blood coagulation | ||||
| PathWhiz Pathway | Vitamin K Metabolism | ||||
| Coagulation | |||||
| Reactome | Intrinsic Pathway of Fibrin Clot Formation | ||||
| Common Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| Cell surface interactions at the vascular wall | |||||
| Peptide ligand-binding receptors | |||||
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | |||||
| G alpha (q) signalling events | |||||
| Thrombin signalling through proteinase activated receptors (PARs) | |||||
| WikiPathways | Complement and Coagulation Cascades | ||||
| Regulation of Actin Cytoskeleton | |||||
| IL1 and megakaryotyces in obesity | |||||
| Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | |||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |||||
| Blood Clotting Cascade | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Thrombin signalling through proteinase activated receptors (PARs) | |||||
| Platelet Aggregation (Plug Formation) | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Formation of Fibrin Clot (Clotting Cascade) | |||||
| Cell surface interactions at the vascular wall | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
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