Drug Information

Drug General Information
Drug ID
D0X0HN
Former ID
DNC004264
Drug Name
LY-317644
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546513]
Structure
Download
2D MOL

3D MOL
Formula
C27H25N3O4
Canonical SMILES
C1CN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCC(OC1)CO)C6=CC=CC=C6<br />5)C(=O)NC4=O
InChI
1S/C27H25N3O4/c31-16-17-10-12-30-15-21(19-7-2-4-9-23(19)30)25-24(26(32)28-27(25)33)20-14-29(11-5-13-34-17)22-8-3-1-6-18(20)22/h1-4,6-9,14-15,17,31H,5,10-13,16H2,(H,28,32,33)
InChIKey
XIFXMAQLEGCDQV-UHFFFAOYSA-N
PubChem Compound ID
15391529
Target and Pathway
Target(s) Protein kinase C, alpha type Target Info Inhibitor [551283]
Protein kinase C, beta type Target Info Inhibitor [551283]
Protein kinase C, zeta type Target Info Inhibitor [551283]
Protein kinase C gamma type Target Info Inhibitor [551283]
Protein kinase C, delta type Target Info Inhibitor [551283]
Protein kinase C, epsilon type Target Info Inhibitor [551283]
Protein kinase C, theta type Target Info Inhibitor [551283]
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
VEGF signaling pathway
Focal adhesion
Tight junction
Gap junction
Natural killer cell mediated cytotoxicity
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Pathogenic Escherichia coli infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
B cell receptor signaling pathway
Carbohydrate digestion and absorption
Leishmaniasis
Choline metabolism in cancerhsa04015:Rap1 signaling pathway
Endocytosis
Hippo signaling pathway
Platelet activation
Insulin signaling pathway
Type II diabetes mellitushsa04010:MAPK signaling pathway
Choline metabolism in cancerhsa04062:Chemokine signaling pathway
Neurotrophin signaling pathway
Estrogen signaling pathway
Type II diabetes mellitushsa04022:cGMP-PKG signaling pathway
Type II diabetes mellitus
MicroRNAs in cancerhsa04064:NF-kappa B signaling pathway
T cell receptor signaling pathway
Adipocytokine signaling pathway
Measles
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PDGF signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
B cell activation
Inflammation mediated by chemokine and cytokine signaling pathway
Metabotropic glutamate receptor group I pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
T cell activation
CCKR signaling map ST
Pathway Interaction Database Endothelins
TCR signaling in na&#xef
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
mTOR signaling pathway
Ras signaling in the CD4+ TCR pathway
ErbB1 downstream signaling
Syndecan-4-mediated signaling events
ATF-2 transcription factor network
PDGFR-beta signaling pathway
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
a6b1 and a6b4 Integrin signaling
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
Fc-epsilon receptor I signaling in mast cells
IL2-mediated signaling events
JNK signaling in the CD4+ TCR pathway
RhoA signaling pathway
Insulin Pathway
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CDC42 signaling events
IL1-mediated signaling events
CXCR4-mediated signaling events
IGF1 pathway
TNF receptor signaling pathway
IL2 signaling events mediated by PI3K
Ceramide signaling pathway
p75(NTR)-mediated signaling
amb2 Integrin signaling
Neurotrophic factor-mediated Trk receptor signaling
Nephrin/Neph1 signaling in the kidney podocyte
Insulin-mediated glucose transport
Regulation of Ras family activationendothelinpathway:Endothelins
IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
LPA receptor mediated events
IFN-gamma pathway
IL6-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
Syndecan-2-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Alpha-synuclein signalingendothelinpathway:Endothelins
LPA4-mediated signaling events
Endothelins
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Calmodulin induced events
Disinhibition of SNARE formation
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Response to elevated platelet cytosolic Ca2+R-HSA-114604:GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferationR-HSA-111933:Calmodulin induced events
Response to elevated platelet cytosolic Ca2+R-HSA-111465:Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-114508:Effects of PIP2 hydrolysis
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
FCERI mediated NF-kB activation
WikiPathways ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
Insulin Signaling
EGF/EGFR Signaling Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Wnt Signaling Pathway Netpath
G Protein Signaling Pathways
Kit receptor signaling pathway
Transcriptional activation by NRF2
Myometrial Relaxation and Contraction Pathways
Human Complement System
Cardiac Hypertrophic Response
Syndecan interactions
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Signaling by SCF-KIT
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
Pathogenic Escherichia coli infection
Signaling Pathways in Glioblastoma
Endothelin Pathways
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
miRs in Muscle Cell Differentiation
Opioid Signalling
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP536:Calcium Regulation in the Cardiac Cell
MAPK Signaling Pathway
Signaling by the B Cell Receptor (BCR)
B Cell Receptor Signaling Pathway
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the HeartWP536:Calcium Regulation in the Cardiac Cell
Signaling by TGF-beta Receptor Complex
Allograft Rejection
TNF alpha Signaling Pathway
IL-1 signaling pathway
GPVI-mediated activation cascade
Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
Response to elevated platelet cytosolic Ca2+WP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
IL-6 signaling pathway
BDNF signaling pathway
GPCR downstream signaling
Effects of PIP2 hydrolysis
Apoptotic execution phase
Type II diabetes mellitusWP666:Hypothetical Network for Drug Addiction
Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
Fc epsilon receptor (FCERI) signaling
TCR signaling
Netrin-1 signaling
References
Ref 546513Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008685)
Ref 551283Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995).

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