Drug General Information
Drug ID
D0X5UN
Former ID
DNAP001695
Drug Name
Mirabegron
Synonyms
Myrbetriq (TN)
Drug Type
Small molecular drug
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Approved [532210], [542469]
Company
Astellas
Structure
Download
2D MOL

3D MOL

Formula
C21H24N4O2S
InChI
InChI=1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
InChIKey
PBAPPPCECJKMCM-IBGZPJMESA-N
CAS Number
CAS 223673-61-8
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:65349
SuperDrug ATC ID
G04BD12
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [532210]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 542469(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7445).
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.

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