Drug Information

Drug General Information
Drug ID
D0Y3KG
Former ID
DCL001031
Drug Name
Valproate
Synonyms
Avugane; Baceca; Convulex; Convulsofin; Depakene; Depakin; Depakine; Deproic; Dipropylacetate; Ergenyl; Mylproin; Savicol; Stavzor; VPA; Valproinsaeure; Vupral; Acide valproique; Acido valproico; Acidum valproicum; Depakin chrono; Depakine chrono; Dipropyl Acetate; Dipropylacetic acid; Med Valproic; Myproic Acid; Propylvaleric acid; Semisodium Valproate; VALPROIC ACID; Valproic acid USP; Abbott 44090; Valproic acid USP24; Acide valproique [INN-French]; Acido valproico [INN-Spanish]; Acidum valproicum [INN-Latin]; Alti-Valproic; Depakene (TN); Depakote (TM); Dom-Valproic; G2M-777; Kyselina 2-propylvalerova; Kyselina 2-propylvalerova [Czech]; N-DPA; N-Dipropylacetic acid; Novo-Valproic; Nu-Valproic; PMS-Valproic Acid; Penta-Valproic; Valproic acid (USP); Di-n-propylacetic acid; Di-n-propylessigsaeure; Di-n-propylessigsaure; Di-n-propylessigsaure [German]; Valproic acid [USAN:INN:BAN]; Valproic Acid, SodiumSalt (2:1); 2 PP (base); 2-Propylpentanoic acid; 2-Propylvaleric acid; 2-n-Propyl-n-valeric acid; 4-Heptanecarboxylic acid
Drug Type
Small molecular drug
Indication Epilepsy [ICD10:G40] Approved [551871]
Alcohol use disorders [ICD9: 303; ICD10:F10.2] Phase 2 [536880]
Therapeutic Class
Neurology Agents
Company
Abbot Phamaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C8H16O2
Canonical SMILES
CCCC(CCC)C(=O)O
InChI
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChIKey
NIJJYAXOARWZEE-UHFFFAOYSA-N
CAS Number
CAS 76584-70-8
PubChem Compound ID
3121
PubChem Substance ID
9394, 399407, 621684, 3138784, 4918409, 7847465, 7980632, 8151988, 10539166, 11335448, 11360687, 11363415, 11364691, 11365977, 11367253, 11368539, 11369815, 11372725, 11372856, 11374010, 11375415, 11376701, 11377978, 11461659, 11484648, 11488762, 11491548, 11492191, 11494335, 12015354, 14710660, 15321539, 17389523, 24898751, 26697333, 26752920, 26752921, 29222263, 46260925, 46505925, 48416692, 48424277, 48425730, 49635685, 49640649, 49856166, 50062089, 50105536, 53788878, 56310655
SuperDrug ATC ID
N03AG01
SuperDrug CAS ID
cas=000099661
Target and Pathway
Target(s) Glycogen synthase kinase-3 Target Info Inhibitor [536096], [536880]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PDGF signaling pathway
Ras Pathway
Pathway Interaction Database Degradation of beta catenin
Canonical Wnt signaling pathway
FOXM1 transcription factor network
Class I PI3K signaling events mediated by Akt
Reactome AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
References
Ref 536880Challenges and new opportunities in the investigation of new drug therapies to treat frontotemporal dementia. Expert Opin Ther Targets. 2008 Nov;12(11):1367-76.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536096Development of medications for alcohol use disorders: recent advances and ongoing challenges. Expert Opin Emerg Drugs. 2005 May;10(2):323-43.
Ref 536880Challenges and new opportunities in the investigation of new drug therapies to treat frontotemporal dementia. Expert Opin Ther Targets. 2008 Nov;12(11):1367-76.

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