Drug Information

Drug General Information
Drug ID
D0Y3UT
Former ID
DNC013432
Drug Name
N-(6-methylpyridin-2-yl)-5-phenylpicolinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528711]
Structure
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2D MOL

3D MOL
Formula
C18H15N3O
Canonical SMILES
CC1=NC(=CC=C1)NC(=O)C2=NC=C(C=C2)C3=CC=CC=C3
InChI
1S/C18H15N3O/c1-13-6-5-9-17(20-13)21-18(22)16-11-10-15(12-19-16)14-7-3-2-4-8-14/h2-12H,1H3,(H,20,21,22)
InChIKey
RDRCRZMPPOKVOV-UHFFFAOYSA-N
PubChem Compound ID
44440732
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528711]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528711Bioorg Med Chem Lett. 2007 Apr 1;17(7):2074-9. Epub 2007 Jan 4.Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists.
Ref 528711Bioorg Med Chem Lett. 2007 Apr 1;17(7):2074-9. Epub 2007 Jan 4.Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists.

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