Drug Information

Drug General Information
Drug ID
D0Z0JU
Former ID
DNC005825
Drug Name
(3-Ethoxy-pyridin-2-yl)-pyridin-2-yl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527656]
Structure
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2D MOL

3D MOL
Formula
C12H13N3O
Canonical SMILES
CCOC1=C(N=CC=C1)NC2=CC=CC=N2
InChI
1S/C12H13N3O/c1-2-16-10-6-5-9-14-12(10)15-11-7-3-4-8-13-11/h3-9H,2H2,1H3,(H,13,14,15)
InChIKey
QXDACVHUAQTTKS-UHFFFAOYSA-N
PubChem Compound ID
11321863
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [527656]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527656Bioorg Med Chem Lett. 2005 Oct 1;15(19):4350-3.Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists.
Ref 527656Bioorg Med Chem Lett. 2005 Oct 1;15(19):4350-3.Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists.

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