Drug General Information
Drug ID	D0Z1OC
Former ID	DNC014414
Drug Name	3-cyano-N-(3-cyanophenyl)-5-fluorobenzamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531010]
Structure		Download 2D MOL 3D MOL
Formula	C15H8FN3O
Canonical SMILES	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC(=C2)C#N)F)C#N
InChI	1S/C15H8FN3O/c16-13-5-11(9-18)4-12(7-13)15(20)19-14-3-1-2-10(6-14)8-17/h1-7H,(H,19,20)
InChIKey	YKPYRZLWZZAYPC-UHFFFAOYSA-N
PubChem Compound ID	49862542
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[531010]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 531010	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.
Ref 531010	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.

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