Drug General Information
Drug ID	D0Z2JF
Former ID	DIB009436
Drug Name	Nivocasan
Synonyms	GS-9450; LB-84451
Indication	Fibrosis [ICD9: 709.2; ICD10:L90.5]		Phase 2	[532482]
Company	LG Life Sciences Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cc2c(c(n1)C1=NO[C@@](C(=O)N[C@@H]3[C@](CF)(O)OC(=O)C3<br />)(C(C)C)C1)cccc2
CAS Number	CAS 908253-63-4
Target and Pathway
Target(s)	Interleukin-1 beta convertase	Target Info	Modulator	[532482]
KEGG Pathway	NOD-like receptor signaling pathway
	Cytosolic DNA-sensing pathway
	Amyotrophic lateral sclerosis (ALS)
	Salmonella infection
	Pertussis
	Legionellosis
	Influenza A
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	IL1-mediated signaling events
	Direct p53 effectors
	IFN-gamma pathway
	Cellular roles of Anthrax toxin
Reactome	NOD1/2 Signaling Pathway
	Interleukin-1 processing
	The NLRP3 inflammasome
WikiPathways	MAPK Signaling Pathway
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
	Apoptosis
	Amyotrophic lateral sclerosis (ALS)
	Parkin-Ubiquitin Proteasomal System pathway
	Interleukin-1 processing
	Apoptosis Modulation and Signaling
	NOD pathway
References
Ref 532482	Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats. Apoptosis. 2013 Dec;18(12):1481-91.
Ref 532482	Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats. Apoptosis. 2013 Dec;18(12):1481-91.

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