TTD | Drug: D0Z4SS

Drug General Information
Drug ID	D0Z4SS
Former ID	DIB018142
Drug Name	[125I]-BDZ2
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541771]
Structure		Download 2D MOL
Formula	C23H19IN4O2
InChI	InChI=1S/C23H19IN4O2/c1-28-19-13-6-5-12-18(19)20(15-8-3-2-4-9-15)26-21(22(28)29)27-23(30)25-17-11-7-10-16(24)14-17/h2-14,21H,1H3,(H2,25,27,30)/t21-/m0/s1/i24-2
InChIKey	VLKJKVMACAESPP-MRDSYVANSA-N
PubChem Compound ID	44572147
PubChem Substance ID	97131209, 103611171, 178103279
Target and Pathway
Target(s)	Gastrin/cholecystokinin type B receptor	Target Info	Antagonist	[530004]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	CCKR signaling map ST
PathWhiz Pathway	Gastric Acid Production
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 541771	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6667).
Ref 530004	Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors. J Med Chem. 2009 Apr 9;52(7):2138-47.

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Drug Information