TTD | Drug: D0Z5WP

Drug General Information
Drug ID	D0Z5WP
Former ID	DIB019852
Drug Name	FD-1
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538694]
Structure		Download 2D MOL
Formula	C28H35N3O6
InChI	InChI=1S/C28H35N3O6/c1-15-12-18-17(27(3,4)14-16(2)28(18,5)6)13-20(15)37-21-11-10-19(36-21)23(32)29-22-24(33-7)30-26(35-9)31-25(22)34-8/h10-13,16H,14H2,1-9H3,(H,29,32)
InChIKey	JTFNDUMPCFHPFC-UHFFFAOYSA-N
PubChem Compound ID	10279142
PubChem Substance ID	15284148, 22656537, 35450346, 75633725, 135650254
Target and Pathway
Target(s)	Gonadotropin-releasing hormone receptor	Target Info	Antagonist	[529377]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	GnRH signaling pathway
NetPath Pathway	IL1 Signaling Pathway
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Hormone ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 538694	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1182).
Ref 529377	Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol Pharmacol. 2008 Jun;73(6):1808-15.

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Drug Information