Drug General Information
Drug ID
D0Z6CZ
Former ID
DNC007195
Drug Name
4,5-dichloro-1H-indole-2,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528749]
Structure
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2D MOL

3D MOL

Formula
C8H3Cl2NO2
Canonical SMILES
C1=CC(=C(C2=C1NC(=O)C2=O)Cl)Cl
InChI
1S/C8H3Cl2NO2/c9-3-1-2-4-5(6(3)10)7(12)8(13)11-4/h1-2H,(H,11,12,13)
InChIKey
WWSWHYAXEFLETD-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Liver carboxylesterase Target Info Inhibitor [528749]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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