Drug Information

Drug General Information
Drug ID
D0Z9UB
Former ID
DNC003843
Drug Name
Bexlosteride
Synonyms
LY-191704
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546722]
Structure
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2D MOL

3D MOL
Formula
C14H16ClNO
Canonical SMILES
CN1C2CCC3=C(C2CCC1=O)C=CC(=C3)Cl
InChI
1S/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m0/s1
InChIKey
WQBIOEFDDDEARX-STQMWFEESA-N
CAS Number
CAS 202189-78-4
PubChem Compound ID
166562
Target and Pathway
Target(s) 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Target Info Inhibitor [525719]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesis
KEGG Pathway Steroid hormone biosynthesis
NetPath Pathway IL2 Signaling Pathway
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Androgen biosynthesis
References
Ref 546722Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009929)
Ref 525719Bioorg Med Chem Lett. 2000 Feb 21;10(4):353-6.Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1.

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