Drug Information

Drug General Information
Drug ID
D0ZJ5K
Former ID
DNC001504
Drug Name
VP-343
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535608]
Structure
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2D MOL

3D MOL
Formula
C32H29N3O3
Canonical SMILES
CC1=CC=C(C=C1)C2=CC=CC=C2C(=O)NC3=CC=C(C=C3)C(=O)N4CC5C<br />C(CN5C6=CC=CC=C64)O
InChI
1S/C32H29N3O3/c1-21-10-12-22(13-11-21)27-6-2-3-7-28(27)31(37)33-24-16-14-23(15-17-24)32(38)35-19-25-18-26(36)20-34(25)29-8-4-5-9-30(29)35/h2-17,25-26,36H,18-20H2,1H3,(H,33,37)/t25-,26+/m1/s1
InChIKey
UACMTQPSUBFZOR-FTJBHMTQSA-N
PubChem Compound ID
9914030
PubChem Substance ID
14884472, 14908971, 24193709, 45985684, 49894174, 79319597, 129338889, 134340675, 142385797
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [535608]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 535608Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.
Ref 535608Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.

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