Drug Information
Drug General Information | |||||
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Drug ID |
D0ZM5W
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Former ID |
DIB011483
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Drug Name |
ESUPRONE
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Synonyms |
LU-43839; Esuprone < Rec INN >; 7-Hydroxy-3,4-dimethyl-2H-1-benzopyran-2-one ethanesulfonate; 7-Hydroxy-3,4-dimethylcoumarin ethanesulfonate
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Drug Type |
Small molecular drug
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Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Discontinued in Phase 2 | [545896] | ||
Structure |
Download2D MOL |
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Formula |
C13H14O5S
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Canonical SMILES |
CCS(=O)(=O)Oc1ccc2C(=C(C)C(=O)Oc2c1)C
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InChI |
1S/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3
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InChIKey |
CHDGAVDQRSPBTA-UHFFFAOYSA-N
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CAS Number |
CAS 91406-11-0
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Amine oxidase [flavin-containing] A | Target Info | Inhibitor | [534393], [551871] | |
KEGG Pathway | Glycine, serine and threonine metabolism | ||||
Arginine and proline metabolism | |||||
Histidine metabolism | |||||
Tyrosine metabolism | |||||
Phenylalanine metabolism | |||||
Tryptophan metabolism | |||||
Drug metabolism - cytochrome P450 | |||||
Metabolic pathways | |||||
Serotonergic synapse | |||||
Dopaminergic synapse | |||||
Cocaine addiction | |||||
Amphetamine addiction | |||||
Alcoholism | |||||
NetPath Pathway | IL4 Signaling Pathway | ||||
References | |||||
Ref 534393 | MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52(2):121-8. | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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