Drug Information
| Drug General Information | |||||
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| Drug ID |
DX1F0G
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| Drug Name |
(3R,5S)-5-((4-(3-chloro-4-(thiazol-4-ylmethoxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL508760
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C27H25ClN6O4S2
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| Canonical SMILES |
Clc1cc(Nc2ncnc3cc(C#C[C@@H]4C[C@H](CN4)OC(=O)N5CCOCC5)sc23)ccc1OCc6cscn6
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| InChI |
InChI=1S/C27H25ClN6O4S2/c28-22-10-18(2-4-24(22)37-13-19-14-39-16-32-19)33-26-25-23(30-15-31-26)11-21(40-25)3-1-17-9-20(12-29-17)38-27(35)34-5-7-36-8-6-34/h2,4,10-11,14-17,20,29H,5-9,12-13H2,(H,30,31,33)/t17-,20-/m1/s1
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| InChIKey |
LYJHHXBOBVEKHY-YLJYHZDGSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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