Drug Information
| Drug General Information | |||||
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| Drug ID |
DXS3M4
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| Drug Name |
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(((2S,4R)-4-ethoxypyrrolidin-2-yl)ethynyl)thieno[3,2-d]pyrimidin-4-amine
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| Synonyms |
CHEMBL497184
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C27H24ClFN4O2S
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| Canonical SMILES |
CCO[C@H]1CN[C@@H](C1)C#Cc2cc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3s2
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| InChI |
InChI=1S/C27H24ClFN4O2S/c1-2-34-21-11-19(30-14-21)6-8-22-13-24-26(36-22)27(32-16-31-24)33-20-7-9-25(23(28)12-20)35-15-17-4-3-5-18(29)10-17/h3-5,7,9-10,12-13,16,19,21,30H,2,11,14-15H2,1H3,(H,31,32,33)/t19-,21-/m1/s1
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| InChIKey |
SFLDOYMGTGAPKO-TZIWHRDSSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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