Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1-methyl-1H-imidazol-2-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(4-(8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 2-(Difluoromethyl)-4-hydroxy-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(6-(pyridin-3-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-imidazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-(dimethylamino)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2-(hydroxymethyl)morpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (R)-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-(2-methylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957845 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(morpholin-4-yl)-6,7-dihydro-4H-spiro[1,3-benzothiazole-5,1'-cyclohexane]-7-one | Drug Info |
| PI3K gamma --- PI3K delta | 3-(6-(1H-indazol-5-ylamino)-2-morpholinopyrimidin-4-yl)phenol | Drug Info |
| PI3K gamma --- PI3K delta | N-(3-(3,5-dimethoxyphenylamino)quinoxalin-2-yl)-4-fluorobenzenesulfonamide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2,2-dimethylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-acetyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl]-phenol | Drug Info |
| PI3K gamma --- PI3K delta | 2-(7-methoxy-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (2R,3aS,5R,5bR,6S,11bR)-2-hydroxy-6-methoxymethyl-3a,5b-dimethyl-3,8,11-trioxo-2,3,3a,4,5,5b,11,11b-octahydro-1H,6H,8H-7,10-dioxa-cyclopenta[j]acephenanthrylen-5-yl ester | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(7-methyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 10-(2-Methyl-3-trifluoromethyl-benzyl)-2-morpholin-4-yl-10H-benzo[4,5]imidazo[1,2-a]pyrimidin-4-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-isopropyl-3-(pyridin-3-ylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(3-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(3-(benzo[b]thiophen-3-ylmethyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957841 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-4-hydroxy-5-methoxy-1H-benzimidazole | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-morpholino-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957840 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(3-aminopropyl)-3-methyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1645108 | Drug Info |
| PI3K gamma --- PI3K delta | (R)-2-(3-benzylmorpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-phenyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(pyrimidin-2-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-2-pyridin-3-yl-thieno[3,2-d]pyrimidine | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(piperazin-1-yl)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (1S,10R,11R,13S,14R)-4-[1-butylsulfanyl-meth-(Z)-ylidene]-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(3-(naphthalen-2-ylmethyl)morpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-ethyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-morpholino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(2-methyl-1H-imidazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-dimethyl-5,6,7,8-tetrahydrothiazolo[5,4-c]azepin-4-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(piperazin-1-yl)pyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-methyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
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